Gradual Reprogramming of Aged Human Cells

Since this used blood cells to make neural stem cells, do you think this could eventually be applied to other cell types in the body?

If the goal is to avoid the all or nothing approach, is it possible we are merely shifting markers without actually restoring full cellular function? Hypothetically, a partial reset might look young on a clock but remain functionally impaired.

While the prospect is exciting, we must be careful about assuming this translates to all cell types. The epigenetic barriers between blood and neural lineages are distinct from those in, for example, cardiomyocytes, which may require entirely different reprogramming factors.

This is the difference between a controlled burn and a forest fire. We are finally stopping the nuke it from orbit approach to cellular aging. Who cares about a total reset if you lose the cell identity in the process?